Neal, born in New Orleans and raised in Baton Rouge, began playing music at a very young age, learning the basics from his father, singer and blues harmonica player, Raful Neal. Family friends like Lazy Lester, Buddy Guy and Slim Harpo also contributed to Kenny’s early musical education. In fact, it was Harpo who gave the crying three-year-old a harmonica to pacify him. Kenny stopped crying that day, and eventually learned to play the harmonica. Along the way, he also mastered the bass, trumpet, piano and guitar. At 13, he joined his father’s band and began paying his musical dues. Four years later, he was recruited and toured extensively as Buddy Guy’s bass player.

Following Buddy's advice to concentrate on his guitar playing, Kenny relocated to Toronto, and along with his brothers Raful, Jr., Noel, Larry and Ronnie - formed the Neal Brothers Band, honing his chops backing up visiting blues stars. Through the years, he has shared the stage or worked with a who’s-who list of blues and R& B greats at one time or another, including B.B. King, Bonnie Raitt, Muddy Waters, Aaron Neville, Buddy Guy and John Lee Hooker. Later, he fronted Canada's Downchild Blues Band, before returning to Baton Rouge to begin his solo career.

Signing with Alligator Records in 1988, Kenny began releasing a series of consistently lauded albums featuring his laid-back, Baton Rouge blues, with a modern spin on the Louisiana sound he grew up with. Throughout this period, Kenny distinguished himself as one of the brightest prospects of the contemporary blues scene, receiving great critical acclaim in the process. The Chicago Tribune pegged Kenny as “one of a mere handful of truly inventive young contemporary guitarists, Neal has something fresh to say and the chops with which to say it,” while AllMusic said his “gruff-before-their-time vocals retain their swamp sensibility, while assuming a bright contemporary feel that tabs him as a leading contender for future blues stardom.” Blues Revue agreed, calling Kenny "one of the brightest young stars on the blues horizon, and a gifted artist."

In 1991, Kenny branched out into the world of acting when he starred as the lead in the much-acclaimed musical, Mule Bone, a lost play written by the famed African-American poet Langston Hughes and folklorist Zora Neale Hurston in 1930. Featuring music written by Taj Mahal, Kenny’s performances garnered a prestigious Theater World Award for “The Most Outstanding New Talent On and Off Broadway,” and he concurrently set two Hughes poems to music on the album Walking With Fire.

After his impressive run with Alligator, Kenny switched to Telarc, and continued to release albums highlighting his developing skills as a songwriter, as well as interpreting songs from musicians as diverse as Bob Dylan, John Hiatt, and Nick Lowe. His 2004 release with Billy Branch, Double Take, garnered Kenny a W.C. Handy award for Best Album. More recently, Kenny released A Tribute to Slim Harpo and Raful Neal, which pays homage to blues harp icon Harpo as well as Kenny’s father, who passed away as the album was being completed.

After relocating to the Bay Area in 2004, Kenny began hosting his own local cable TV program, “Neal’s Place.” The show features Kenny jamming and talking with the many international blues stars he has met and performed with, as well as local artists he has spotted at festivals and clubs. Filmed in front of a live studio audience, “Neal’s Place” has a relaxed, informal atmosphere that brings out the best in the artists, while giving an unscripted, improvisational edge to the performances.

Commenting on his recent return to recording and performing with Let Life Flow, Kenny said: “With all the tragedy and darkness I’ve been through in the past three years, I’m finally seeing the light. I’ve been waiting for a long time for a record company to say ‘Make a record that you feel good about.’ Blind Pig Records gave me that opportunity. And my new CD, Let Life Flow, is coming straight from my heart. Hope everyone enjoys it.”